Endocrine Abstracts

Background: Amiodarone is an antiarrhytmic drug used mainly in atrial fibrillation. Amiodarone-induced thyrotoxicosis (AIT) is less common than hypothyroidism, but it represents a true therapeutic challenge. AIT can be due iodine load (type 1) or a destructive thyroiditis (type 2).Methods: Retrospective study of patients with AIT, diagnosed between 2010 and 2015, in a central hospital. We reviewed medical records regarding age, gender, amiodarone therapy...

Background: Fine-needle aspiration (FNA) is an important test for triaging patients with thyroid nodules and differentiating benign from malignant disease. According to Bethesda System Classification, the rate of AUS/FLUS is between 3–6% of all FNA. The malignancy risk is of 5–15%. TSH levels might be associated to the likelihood of malignancy in thyroid nodules according to some studies. Our aim was to establish a possible correlation between TSH level and malignanc...

Context: Insulin resistance is an important component of polycystic ovary syndrome (PCOS). Local cytokine production in adipose tissue increases local insulin resistance. The effect of testosterone on local adipose tissue cytokine production has not been explored thoroughly.Aim: To evaluate cytokine expression in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from PCOS and control women and evaluate the response to testosterone on th...

Introduction: 25-hydroxyvitamin D (25(OH)D3) deficiency has been associated with diabetes and obesity. However, the mechanisms underlying these relationships are not completely understood. Vitamin D receptor (VDR) is expressed in adipose tissue; it has been reported a higher expression in obese patients than in lean subjects, suggesting a differential vitamin D dynamics in adipose tissue according to the obesity degree. In addition, 1, 25-dihydroxyvitamin D3 (1,25(OH)2D3) is a...

Introduction: In preliminary results of our group, we detected an association between the mean nocturnal blood pressure and development microvascular complications. The objective was to evaluate possible nocturnal blood pressure cut off points in relation to the development or progression of retinopathy, microalbuminuria and arterial hypertension in type 1 diabetic patients.Methods: We designed a prospective observational study of 85 patients, clinically...

Background and aims: The relationship between gestational diabetes mellitus (GDM) and oxidative stress is not well known and the effect of both oxidative and nitrosative stress in GDM placenta and the impact that could have on perinatal morbidity and risk of future complications is still pending to be elucidated. The aim of the study was to evaluate the relationships between maternal and placental tissue levels of markers of nitrosative and oxidative stress and antioxidants in...

Background: Optimal management of type 1 diabetes requires full understanding of the relationships between the triad: HbA1c, fasting plasma glucose, and glucose variability (GV). As GV may contribute to HbA1c we assessed the influence of GV in HbA1c levels.Research design and methods: We retrospectively analysed 9393 h of continuous glucose monitorings (CGMs) from 61 patients with type 1 diabetes. Periods of 24 h with missing values were excluded. We cal...

Introduction: Cushing’s disease (CD) is characterized by increased secretion of ACTH often as a result of a pituitary adenoma. The surgical success rates after transsphenoidal pituitary surgery (TSS) range from 53 to 96% in different centres. Postoperative cortisol levels have been proposed as the standard criteria for prediction of surgical remission however, this variable is subject of a variety of interferences.Objectives: Evaluate the potential ...

Introduction: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by proliferation/accumulation of cells phenotypically similar to skin Langerhans cells. Clinical presentation and aggressiveness are very heterogeneous, from benign to disseminated forms that cause significant morbi-mortality, particularly endocrine failures.Case 1: A 15-year-old Caucasian woman presented with a 14-month history of headaches, secondary amenorrhea. She repo...

Introduction: Interferon treatment for hepatitis C has been associated with Graves’-like thyroiditis, developing in rare instances severe ophthalmopathy. The usual management is interferon withdrawal and high-dose corticosteroids, but it may interfere with the resolution of hepatitis. Hereby we report a case successfully treated with radiotherapy, which in our knowledge has never been previously reported.Case report: A 52-year-old woman was diagnose...